ACT

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells

Medicinal name:
  • Risedronate sodium 5 MG Oral Tablet [Actonel]
  • Doxycycline 75 MG Oral Tablet [Acticlate]
  • Risedronate sodium 30 MG Oral Tablet [Actonel]
  • 24 HR Metformin hydrochloride 1000 MG / pioglitazone 30 MG Extended Release Oral Tablet [Actoplus Met]
  • Pioglitazone 15 MG Oral Tablet [Actos]
  • Pack [Actonel 35 4-Week]
  • Metformin hydrochloride 500 MG / pioglitazone 15 MG Oral Tablet [Actoplus Met]
  • Metformin hydrochloride 850 MG / pioglitazone 15 MG Oral Tablet [Actoplus Met]
  • Pioglitazone 45 MG Oral Tablet [Actos]
  • Risedronate sodium 150 MG Oral Tablet [Actonel]
  • Pack [Actonel 75]
  • Pioglitazone 30 MG Oral Tablet [Actos]
  • Doxycycline 150 MG Oral Tablet [Acticlate]
  • Ursodiol 300 MG Oral Capsule [Actigall]
  • Pack [Activella 0.5/0.1 28 Day]
  • 24 HR Metformin hydrochloride 1000 MG / pioglitazone 15 MG Extended Release Oral Tablet [Actoplus Met]
  • Pack [Activella 1/0.5 28 Day]

ACT - Pharmacology:

Cleaves the Arg-Val bond in plasminogen to produce active plasmin.

ACT for patients

Activase is a drug that is only administered intravenously by trained doctors to patients in acute emergency situations. These doctors are trained to treat blood clots that need to be dissolved quickly. See indications for its use under Indications and Dosages.

ACT Interactions

The interaction of Activase with other cardioactive or cerebroactive drugs has not been studied. In addition to bleeding associated with heparin and vitamin K antagonists, drugs that alter platelet function (such as acetylsalicylic acid, dipyridamole and Abciximab) may increase the risk of bleeding if administered prior to, during, or after Activase therapy.

Use of Antithrombotics Aspirin and heparin have been administered concomitantly with and following infusions of Activase in the management of acute myocardial infarction or pulmonary embolism. Because heparin, aspirin, or Activase may cause bleeding complications, careful monitoring for bleeding is advised, especially at arterial puncture sites.

The concomitant use of heparin or aspirin during the first 24 hours following symptom onset were prohibited in The NINDS t-PA Stroke Trial. The safety of such concomitant use with Activase for the management of acute ischemic stroke is unknown.

ACT Contraindications

Acute Myocardial Infarction or Pulmonary Embolism

Activase®, ACT, recombinant, therapy in patients with acute myocardial infarction or pulmonary embolism is contraindicated in the following situations because of an increased risk of bleeding:

  • Active internal bleeding
  • History of cerebrovascular accident
  • Recent intracranial or intraspinal surgery or trauma
  • Intracranial neoplasm, arteriovenous malformation, or aneurysm
  • Known bleeding diathesis
  • Severe uncontrolled hypertension

Acute Ischemic Stroke Activase therapy in patients with acute ischemic stroke is contraindicated in the following situations because of an increased risk of bleeding, which could result in significant disability or death:

  • Evidence of intracranial hemorrhage on pretreatment evaluation
  • Suspicion of subarachnoid hemorrhage
  • Recent intracranial surgery or serious head trauma or recent previous stroke
  • History of intracranial hemorrhage
  • Uncontrolled hypertension at time of treatment (e.g., > 185 mm Hg systolic or > 110 mm Hg diastolic)
  • Seizure at the onset of stroke
  • Active internal bleeding
  • Intracranial neoplasm, arteriovenous malformation, or aneurysm
  • Known bleeding diathesis including but not limited to:
    • Current use of oral anticoagulants (e.g., warfarin sodium) with prothrombin time (PT) > 15 seconds
    • Administration of heparin within 48 hours preceding the onset of stroke and have an elevated activated partial thromboplastin time (aPTT) at presentation

Manufacturers name:

  • Warner Chilcott Pharmaceuticals Inc
  • Aqua Pharmaceuticals
  • Pharmaceutica North America, Inc
  • Warner Chilcott (US), LLC
  • GM Pharmaceuticals, Inc
  • Takeda Pharmaceuticals America, Inc
  • REMEDYREPACK INC
  • Cardinal Health
  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • Physicians Total Care, Inc
  • Rebel Distributors Corp
  • Dispensing Solutions, Inc
  • Watson Pharma, Inc
  • Novo Nordisk

ACT tags categories:

Generic name, Overdose, Half Life ACT, Food Interactions, Chemical, etc..

ACT see also FDA report Anise

Skin Care
Brand Names containing Alteplase