ADM

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of daunorubicin. .
[PubChem].

ADM - Pharmacology:

ADM has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: ADM forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

ADM for patients

Patients and their caregivers should be informed of the expected adverse effects of DOXIL® , particularly hand-foot syndrome, stomatitis, and neutropenia and related complications of neutropenic fever, infection, and sepsis.

Hand-Foot Syndrome (HFS): Patients who experience tingling or burning, redness, flaking, bothersome swelling, small blisters, or small sores on the palms of their hands or soles of their feet (symptoms of Hand-Foot Syndrome) should notify their physician.

Stomatitis: Patients who experience painful redness, swelling, or sores in the mouth (symptoms of stomatitis) should notify their physician.

Fever and Neutropenia Patients who develop a fever of 100.5°F or higher should notify their physician.

Nausea, vomiting, tiredness, weakness, rash, or mild hair loss Patients who develop any of these symptoms should notify their physician.

Following its administration, DOXIL® may impart a reddish orange color to the urine and other body fluids. This nontoxic reaction is due to the color of the product and will dissipate as the drug is eliminated from the body.

ADM Interactions

No formal drug interaction studies have been conducted with DOXIL® . Until specific compatibility data are available, it is not recommended that DOXIL® be mixed with other drugs. DOXIL® may interact with drugs known to interact with the conventional formulation of doxorubicin HCl.

ADM Contraindications

DOXIL® (doxorubicin HCl liposome injection) is contraindicated in patients who have a history of hypersensitivity reactions to a conventional formulation of doxorubicin HCl or the components of DOXIL®.

DOXIL® IS CONTRAINDICATED IN NURSING MOTHERS.

ADM tags categories:

Generic name, Overdose, Half Life ADM, Food Interactions, Chemical, etc..

ADM see also

Brand Names containing Doxorubicin