AR3

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. AR3 is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

AR3 - Pharmacology:

AR3 acts through direct DNA damage and incorporation into DNA. AR3 is cytotoxic to a wide variety of proliferating mammalian cells in culture. It exhibits cell phase specificity, primarily killing cells undergoing DNA synthesis (S-phase) and under certain conditions blocking the progression of cells from the G1 phase to the S-phase. Although the mechanism of action is not completely understood, it appears that cytarabine acts through the inhibition of DNA polymerase. A limited, but significant, incorporation of cytarabine into both DNA and RNA has also been reported.

AR3 for patients

This medicine is a type of chemotherapy for treating cancers of the
blood and certain other cancers. This medicine interfers with the
way cancer cells grow, Take your doses on a regular scheduled time
and DO NOT take this medicine more often than directed by your health
care provider. Finish the full course prescribed by your health care
provider. DO NOT stop taking this medicine unless diredted to do so
by your health care provider. While taking this medicine, you make
get infection more easily. Call your doctor if you get a fever, chills,
or sore throat. Drink plenty of water with this medicine.

AR3 Interactions

Reversible decreases in steady-state plasma digoxin concentrations and
renal glycoside excretion were observed in patients receiving beta-acetyl
digoxin and chemotherapy regimens containing cyclophosphamide, vincristine,
and prednisone with or without cytarabine or procarbazine. Steady state
plasma digitoxin concentrations did not appear to change. Therefore,
monitoring of plasma digoxin levels may be indicated in patients receiving
similar combination chemotherapy regimens. The utilization of digitoxin for
such patients may be considered as an alternative. Also flucytosine.

AR3 Contraindications

AR3 is contraindicated in those patients who are hypersensitive to the drug.

AR3 tags categories:

Generic name, Overdose, Half Life AR3, Food Interactions, Chemical, etc..

AR3 see also

Brand Names containing Cytarabine