Accupril

Accupril is used in the treatment of hypertension and congestive heart failure. Accupril is actually a prodrug. It is converted to its active metabolite, quinaprilat, in the liver. Accupril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms.

Medicinal name:
  • Quinapril 10 MG Oral Tablet [Accupril]
  • Quinapril 20 MG Oral Tablet [Accupril]
  • Quinapril 40 MG Oral Tablet [Accupril]
  • Quinapril 5 MG Oral Tablet [Accupril]

Accupril - Pharmacology:

Accuprilat competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms. Accuprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

Accupril mini report

Accupril NDA
NDA - A product marketed under an approved New Drug Application
Accupril TABLET, FILM COATED
TABLET, FILM COATED
Accupril HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Accupril global name
quinapril hydrochloride
Start - Stop data
START DATA:
1991-Nov-19
Start - Stop data
STOP DATA
not occurred

Accupril for patients

PATIENT INFORMATION

Pregnancy

Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to ACE
inhibitors, and they should also be told that these consequences do not appear to have resulted from intrauterine ACE-inhibitor
exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians
as soon as possible.

Angioedema

Angioedema, including laryngeal edema can occur with treatment with ACE inhibitors, especially following the first dose. Patients
should be so advised and told to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities,
eyes, lips, tongue, difficulty in swallowing or breathing) and to stop taking the drug until they have consulted with their physician.

Symptomatic hypotension

Patients should be cautioned that lightheadedness can occur, especially during the first few days of ACCUPRIL therapy, and that it
should be reported to a physician. If actual syncope occurs, patients should be told to not take the drug until they have consulted
with their physician.

All patients should be cautioned that inadequate fluid intake or excessive perspiration, diarrhea, or vomiting can lead to an
excessive fall in blood pressure because of reduction in fluid volume, with the same consequences of lightheadedness and possible
syncope.

Patients planning to undergo any surgery and/or anesthesia should be told to inform their physician that they are taking an ACE
inhibitor.

Hyperkalemia

Patients should be told not to use potassium supplements or salt substitutes containing potassium without consulting their physician.

Neutropenia

Patients should be told to report promptly any indication of infection (eg, sore throat, fever) which could be a sign of neutropenia.

NOTE: As with many other drugs, certain advice to patients being treated with ACCUPRIL is warranted. This information is intended to
aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

Accupril Interactions

Concomitant diuretic therapy

As with other ACE inhibitors, patients on diuretics, especially those on recently instituted diuretic therapy, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with ACCUPRIL. The possibility of hypotensive effects with ACCUPRIL may be minimized by either discontinuing the diuretic or cautiously increasing salt intake prior to initiation of treatment with ACCUPRIL. If it is not possible to discontinue the diuretic, the starting dose of quinapril should be reduced.

Agents increasing serum potassium

Accupril can attenuate potassium loss caused by thiazide diuretics and increase serum potassium when used alone. If concomitant therapy of ACCUPRIL with potassium-sparing diuretics (eg, spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes is indicated, they should be used with caution along with appropriate monitoring of serum potassium.

Tetracycline and other drugs that interact with magnesium

Simultaneous administration of tetracycline with ACCUPRIL reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in ACCUPRIL tablets. This interaction should be considered if coprescribing ACCUPRIL and tetracycline or other drugs that interact with magnesium.

Lithium

Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity.

Other agents

Drug interaction studies of ACCUPRIL with other agents showed:

· Multiple dose therapy with propranolol or cimetidine has no effect on the pharmacokinetics of single doses of ACCUPRIL.

· The anticoagulant effect of a single dose of warfarin (measured by prothrombin time) was not significantly changed by quinapril coadministration twice-daily.

· ACCUPRIL treatment did not affect the pharmacokinetics of digoxin.
· No pharmacokinetic interaction was observed when single doses of ACCUPRIL and hydrochlorothiazide were administered concomitantly.

· Co-administration of multiple 10 mg doses of atorvastatin with 80 mg of ACCUPRIL resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.

Accupril Contraindications

ACCUPRIL is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.

Manufacturers name:

  • Cardinal Health
  • Parke-Davis Div of Pfizer Inc
  • Bryant Ranch Prepack

Generic name, Overdose, Half Life Accupril, Food Interactions, Chemical, etc..

Accupril see also FDA report Barrenwort

Brand Names containing Quinapril
Blood Pressure