Adaferin - General Information:Adaferin is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. [Wikipedia]
Other Brand Names containing Adapalene
Adaferin - Pharmacology:
Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Adaferin for patients
Patients using DIFFERIN® (Adapalene) Cream should receive the following information and instructions:
- This medication is to be used only as directed by the physician.
- It is for external use only.
- Avoid contact with the eyes, lips, angles of the nose, and mucous membranes.
- Cleanse area with a mild or soapless cleanser before applying this medication.
- Moisturizers may be used if necessary; however, products containing alpha hydroxy or glycolic acids should be avoided.
- Exposure of the eye to this medication may result in reactions such as swelling, conjunctivitis, and eye irritation.
- This medication should not be applied to cuts, abrasions, eczematous or sunburned skin.
- Wax epilation should not be performed on treated skin due to the potential for skin erosions.
- During the early weeks of therapy, an apparent exacerbation of acne may occur. This is due to the action of this medication on previously unseen lesions and should not be considered a reason to discontinue therapy. Overall clinical benefit may be noticed after two weeks of therapy, but at least eight weeks are required to obtain consistent beneficial effects.
As DIFFERIN Gel has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime) should be approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with DIFFERIN Gel. If these preparations have been used it is advisable not to start therapy with DIFFERIN Gel until the effects of such preparations in the skin have subsided.
DIFFERIN Gel should not be administered to individuals who are hypersensitive to adapalene or any of the components in the vehicle gel.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..