As DIFFERIN Gel has the potential to produce local irritation in some patients, concomitant use of other
potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a
strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime) should be
approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol,
or salicylic acid in combination with DIFFERIN Gel. If these preparations have been used it is advisable not to start
therapy with DIFFERIN Gel until the effects of such preparations in the skin have subsided.