Altace Indication:

For diuretics and digitalis in congestive heart failure as adjunctive therapy and for use in prophylaxis in post MI.

Altace Mechanism Of Action:

Altaceat, the active metabolite, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and an increase in plasma renin. Altaceat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

Altace Drug Interactions:

Drospirenone Increased risk of hyperkaliemia
Amiloride Increased risk of hyperkaliemia
Potassium Increased risk of hyperkaliemia
Lithium The ACE inhibitor increases serum levels of lithium
Spironolactone Increased risk of hyperkaliemia
Triamterene Increased risk of hyperkaliemia
Tizanidine Tizanidine increases the risk of hypotension with the ACE inhibitor

Altace Food Interactions:

Not Available

Altace Generic Name:

Synonyms:

  • Ramiprilum [Latin]

Drug Type:

Small Molecule; Approved

Absorption:

The extent of absorption is at least 50-60% and is not significantly influenced by the presence of food in the GI tract, although the rate of absorption is reduced.

Toxicity (Overdose):

The most likely clinical manifestations would be symptoms attributable to hypotension. LD50 = 10933 mg/kg (orally in mice).

Protein Binding:

Protein binding of ramipril is about 73% and that of ramiprilat about 56%. The absolute bioavailabilities of ramipril and ramiprilat were 28% and 44%, respectively.

Biotransformation:

Hepatic. Ramipril is a prodrug and is converted to the active metabolite ramiprilat by liver esterase enzymes.

Half Life:

2-4 hours

Dosage Forms of Altace:

Capsule Oral

Chemical IUPAC Name:

(2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[d]pyrrole-2-carboxylic acid

Organisms Affected:

Humans and other mammals

Altace to general, pharmacology

General, pharmacology..