Androgel Indication:

For replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone.

Androgel Mechanism Of Action:

The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

Androgel Drug Interactions:

Not Available

Androgel Food Interactions:

Not Available

Androgel Generic Name:

Synonyms:

  • Testosterona [Inn-Spanish]
  • Testosteronum [Inn-Latin]
  • TES
  • Testosterone Hydrate
  • Testosterone Enanthate
  • Testosterone Cypionate
  • Testostosterone
  • Testosteron
  • Trans-Testosterone
  • Dea No. 4000

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

Approximately 10% of the testosterone dose applied on the skin surface is absorbed into systemic circulation

Toxicity (Overdose):

Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.

Protein Binding:

40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins.

Biotransformation:

Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).

Half Life:

10-100 minutes

Dosage Forms of Androgel:

Gel Topical
Patch Transdermal
Capsule Oral
Solution Intramuscular
Liquid Intramuscular

Chemical IUPAC Name:

(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Organisms Affected:

Humans and other mammals

Androgel to general, pharmacology

General, pharmacology..