Oxyphenbutazone: Concurrent administration of oxyphenbutazone and androgens may result in elevated
serum levels of oxyphenbutazone.
Insulin: In diabetic patients, the metabolic effects of androgens may decrease blood glucose and,
therefore, insulin requirements.
Propranolol: In a published pharmacokinetic study of an injectable testosterone product,
administration of testosterone cypionate led to an increased clearance of propranolol in the majority of men
Corticosteroids: The concurrent administration of testosterone with ACTH or corticosteroids may
enhance edema formation; thus, these drugs should be administered cautiously, particularly in patients with cardiac
or hepatic disease.
Drug/Laboratory Test Interactions
Androgens may decrease levels of thyroxin-binding globulin, resulting in decreased total T4 serum levels and
increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical
evidence of thyroid dysfunction.