Antabuse Indication:

For the treatment and management of chronic alcoholism

Antabuse Mechanism Of Action:

Antabuse blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Antabuse blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied.

Antabuse Drug Interactions:

Aminophylline Increases the effect and toxicity of theophylline
Amprenavir Increased risk of side effects (oral solution)
Anisindione Increases the anticoagulant effect
Chlorzoxazone Increases chlorzoxazone levels
Cocaine Increases the cardiac toxicity of cocaine
Dicumarol Increases the anticoagulant effect
Dyphylline Increases the effect and toxicity of theophylline
Ethotoin Increases the effect of phenytoin
Fosphenytoin Increases the effect of phenytoin
Isoniazid Increased risk of CNS adverse efects
Mephenytoin Increases the effect of phenytoin
Metronidazole Possible acute psychosis and confusion
Oxtriphylline Increases the effect and toxicity of theophylline
Phenytoin Increases the effect of phenytoin
Theophylline Increases the effect and toxicity of theophylline
Warfarin Increases the anticoagulant effect
Acenocoumarol Antabuse increases the anticoagulant effect

Antabuse Food Interactions:

Take without regard to meals.
Avoid alcohol for up to 14 days after treatment has been stopped.

Antabuse Generic Name:

Synonyms:

  • Dupon 4472
  • Dupont Fungicide 4472
  • Disulfuram
  • Disulphuram
  • TATD
  • TETD
  • Tetraethylthioperoxydicarbonic Diamide
  • Tetraethylthiram Disulfide
  • Tetraethylthiram Disulphide
  • Tetraethylthiuram
  • Tetraethylthiuram Disulfide
  • Tetraethylthiuram Disulphide
  • Tetraethylthiuram Sulfide
  • Tetraethylthiuran Disulfide
  • TTD
  • Usaf B-33

Drug Type:

Small Molecule; Approved

Absorption:

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Toxicity (Overdose):

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Protein Binding:

Not Available

Biotransformation:

Hepatic.

Half Life:

Not Available

Dosage Forms of Antabuse:

Tablet Oral

Chemical IUPAC Name:

diethylcarbamothioylsulfanyl diethylaminomethanedithioate

Organisms Affected:

Humans and other mammals

Antabuse to general, pharmacology

General, pharmacology..
General health