Avodart Indication:

For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland.

Avodart Mechanism Of Action:

Avodart inhibits the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT). DHT is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to DHT by the enzyme 5 alpha-reductase, which exists as 2 isoforms, type 1 and type 2. The type 2 isoenzyme is primarily active in the reproductive tissues while the type 1 isoenzyme is also responsible for testosterone conversion in the skin and liver. Avodart is a competitive and specific inhibitor of both type 1 and type 2 5 alpha-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Avodart does not bind to the human androgen receptor.

Avodart Drug Interactions:

Not Available

Avodart Food Interactions:

Take without regard to meals.

Avodart Generic Name:

Synonyms:

  • Not Available

Drug Type:

Small Molecule; Approved

Absorption:

60%

Toxicity (Overdose):

Not Available

Protein Binding:

99%

Biotransformation:

Hepatic. Extensively metabolized.

Half Life:

5 weeks

Dosage Forms of Avodart:

Capsule Oral

Chemical IUPAC Name:

(1S,3aS,3bS,5aR,9aR,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide

Organisms Affected:

Humans and other mammals

Avodart to general, pharmacology

General, pharmacology..
Men's Health