Bactroban

Bactroban (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Bactroban is bacteriostatic at low concentrations and bactericidal at high concentrations.
Bactroban has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.

Bactroban - Pharmacology:

Bactroban reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA, resulting in the inhibition of bacterial protein and RNA synthesis.

Bactroban mini report

Bactroban NDA
NDA - A product marketed under an approved New Drug Application
Bactroban CREAM
CREAM
Bactroban OINTMENT
OINTMENT
Bactroban HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Bactroban global name
mupirocin calcium
Bactroban global name
mupirocin
Start - Stop data
START DATA:
1998-Jan-23
Start - Stop data
STOP DATA
not occurred

Bactroban for patients

Patients should be given the following instructions:

  • Apply approximately one-half of the ointment from the single-use tube directly into one nostril and the other half into the other nostril;
  • Avoid contact of the medication with the eyes;
  • Discard the tube after using, do not re-use;
  • Press the sides of the nose together and gently massage after application to spread the ointment throughout the inside of the nostrils; and
  • Discontinue usage of the medication and call your health care practitioner if sensitization or severe local irritation occurs.

Bactroban Interactions

No information provided.

Bactroban Contraindications

This drug is contraindicated in individuals with a history of sensitivity reactions to any of its components.

Bactroban tags categories:

Generic name, Overdose, Half Life Bactroban, Food Interactions, Chemical, etc..

Bactroban see also

Brand Names containing Mupirocin