Biomycin - General Information:

A tetracycline with a 7-chloro substitution. [PubChem]

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Biomycin - Pharmacology:

Biomycin inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Biomycin is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Cells become resistant to lymecycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps lymecycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents lymecycline from acting on the ribosome.

Biomycin for patients

Lymecycline is an antibiotic. It should not be administered to pregnant women or children below the age of 8 years. Patients with kidney or liver disease should use it with caution. Patients who are pregnant or breastfeeding should discuss about the risks with the doctors.

Patients may experience the following signs/symptoms while taking Lymecycline:

  • Headache
  • Rash
  • Diarrhoea
  • Visual disturbances
  • Inflammation of the pancreas
  • Inflammation of the large intestine
  • Damage to the liver
  • Nausea and vomiting
  • Abnormal reaction of the skin to light, usually a rash

Patients should be advised not to take any indigestion remedies, iron or zinc supplements at the same time as this medicine. Take them at least two hours before or two hours after lymecycline.

Biomycin Interactions

The absorption of lymecycline may be affected by the simultaneous administration of indigestion remedies, iron or zinc supplements.

Oral contraceptives may be less effective while you are taking lymecycline.

Biomycin Contraindications

Lymecycline should not be used in children under 12 years of age, patients with long-term inflammation of skin and organs, and patients who are allergic to lymecycline.

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