Black Leaf 40 - General Information:

Black Leaf 40 is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Black Leaf 40 is also important medically because of its presence in tobacco smoke. [PubChem]

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Black Leaf 40 - Pharmacology:

Black Leaf 40 binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone.

Black Leaf 40 for patients

A patient information sheet is included in the package of NICOTROL Inhaler cartridges dispensed to the patient. Patients should be encouraged to read the information sheet carefully and to ask their physician and pharmacist about the proper use of the product .

Patients must be advised to keep both used and unused cartridges out of the reach of children and pets.

Black Leaf 40 Interactions

Physiological changes resulting from smoking cessation, with or without nicotine replacement, may alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline. Doses of these and perhaps other medications may need to be adjusted in patients who successfully quit smoking.

Black Leaf 40 Contraindications

Use of NICOTROL Inhaler therapy is contraindicated in patients with known hypersensitivity or allergy to nicotine or to menthol.

Black Leaf 40 more info

Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..
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