No significant drug interactions have been reported in studies of candesartan cilexetil given with other drugs
such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide, and oral contraceptives in healthy volunteers,
or given with enalapril to patients with heart failure (NYHA class II and III). Because candesartan is not
significantly metabolized by the cytochrome P450 system and at therapeutic concentrations has no effects on P450
enzymes, interactions with drugs that inhibit or are metabolized by those enzymes would not be expected.
Lithiumó Reversible increases in serum lithium concentrations and toxicity have been reported during
concomitant administration of lithium with ACE inhibitors, and with some angiotensin II receptor antagonists. An
increase in serum lithium concentration has been reported during concomitant administration of lithium with ATACAND,
so careful monitoring of serum lithium levels is recommended during concomitant use.