Campath

Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.

Campath - Pharmacology:

Campath binds to the CD52 antigen present on most B and T lymphocytes. This binding leads to antibody-dependent lysis of leukemic cells.

Campath mini report

Campath BLA
BLA - A product marketed under an approved Biologic License Application
Campath INTRAVENOUS
INTRAVENOUS
Campath HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Start - Stop data
START DATA:
2009-Nov-30
Start - Stop data
STOP DATA
not occurred

Campath Interactions

Drug/Laboratory Interactions

No formal drug interaction studies have been performed with Campath. An immune response to Campath may interfere with subsequent diagnostic serum tests that utilize antibodies.

 

 

Campath Contraindications

Campath is contraindicated in patients who have active systemic infections, underlying immunodeficiency (e.g.,seropositive for HIV),or known Type I hypersensitivity or anaphylactic reactions to Campath or to any one of its components.

Generic name, Overdose, Half Life Campath, Food Interactions, Chemical, etc..

Campath see also