Cardizem Indication:

For the treatment of Hypertension

Cardizem Mechanism Of Action:

Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, dilitiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.

Cardizem Drug Interactions:

Amiodarone Increased risk of cardiotoxicity and arrhythmias
Amlodipine Increases the effect and toxicity of amlodipine
Aprepitant This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Atazanavir Atazanavir increases the effect and toxicity of diltiazem
Atenolol Increased risk of bradycardia
Atorvastatin Increases the effect and toxicity of atorvastatin
Buspirone The calcium channel blocker increases the effect and toxicity of buspirone
Carbamazepine Increases the effect of carbamazepine
Cerivastatin Increases the effect and toxicity of the statin
Cilostazol Increases the effect of cilostazol
Cisapride Increases the levels of cisapride
Cyclosporine Increases the effect and toxicity of cyclosporine
Dihydroquinidine barbiturate Increases the effect and toxicity of quinidine
Lovastatin Increases the effect and toxicity of the statin
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Metoprolol Increased risk of bradycardia
Midazolam The calcium channel blocker increases the effect and toxicity of the benzodiazepine
Moricizine Increased effect/toxicity of moricizine
Pindolol Increased risk of bradycardia
Propranolol Increased risk of bradycardia
Quinidine Increases the effect and toxicity of quinidine
Quinidine barbiturate Increases the effect and toxicity of quinidine
Quinupristin This combination presents an increased risk of toxicity
Ranolazine Increased levels of ranolazine- risk of toxicity
Rifampin Rifampin decreases levels of diltiazem
Ritonavir Ritonavir increases diltiazem levels
Simvastatin Increases the effect and toicity of simvastatin
Sirolimus Increases the effect and toxicity of sirolimus
Tacrolimus Increases levels of tacrolimus
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Triazolam The calcium channel blocker increases the effect and toxicity of the benzodiazepine

Cardizem Food Interactions:

Take this medication 30 minutes before meals.
Avoid natural licorice.

Cardizem Generic Name:

Synonyms:

  • d-cis-Diltiazem

Drug Type:

Small Molecule; Approved

Absorption:

Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.

Toxicity (Overdose):

LD50=740mg/kg (orally in mice)

Protein Binding:

70%-80%

Biotransformation:

Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.

Half Life:

3.0 - 4.5 hours

Dosage Forms of Cardizem:

Solution Intravenous
Liquid Intravenous
Tablet, extended release Oral
Tablet Oral
Capsule, extended release Oral

Chemical IUPAC Name:

[(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate

Organisms Affected:

Humans and other mammals

Cardizem to general, pharmacology

General, pharmacology..