Cialis Indication:

Used for the treatment of erectile dysfunction

Cialis Mechanism Of Action:

Cialis inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by tadalafil enhances erectile function by increasing the amount of cGMP.

Cialis Drug Interactions:

Not Available

Cialis Food Interactions:

Not Available

Cialis Generic Name:

Synonyms:

  • CIA
  • ICOS 351
  • Tadanafil

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

After single oral-dose administration, the maximum observed plasma concentration (Cmax) of tadalafil is achieved between 30 minutes and 6 hours (median time of 2 hours). Absolute bioavailability of tadalafil following oral dosing has not been determined.

Toxicity (Overdose):

Oral, Rat LD50 = 2000 mg/kg, no deaths or toxicity.

Protein Binding:

94%

Biotransformation:

Tadalafil is predominantly metabolized by CYP3A4 to a catechol metabolite. The catechol metabolite undergoes extensive methylation and glucuronidation to form the methylcatechol and methylcatechol glucuronide conjugate, respectively. In vitro data suggests the metabolites are not expected to be pharmacologically active at observed metabolite concentrations.

Half Life:

17.5 hours

Dosage Forms of Cialis:

Tablet Oral

Chemical IUPAC Name:

(6R-trans)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Organisms Affected:

Humans and other mammals

Cialis to general, pharmacology

General, pharmacology..
Men's Health