Clozaril Indication:

For the management of severely ill schizophrenic patients who fail to respond adequately to standard drug treatment for schizophrenia

Clozaril Mechanism Of Action:

The mechanism of action of Clozaril, as with other drugs used to treat schizophrenia, is unknown. However, it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of dopamine Type 2 (D2) and serotonin Type 2 (5HT2) receptor antagonism.

Clozaril Drug Interactions:

Alprazolam Increased risk of toxicity
Caffeine Caffeine increases the effect and toxicity of clozapine
Carbamazepine Carbamazepine decreases the effect of clozapine, hematologic toxicity
Chlordiazepoxide Increased risk of toxicity
Cimetidine Cimetidine increases the effect of clozapine
Ciprofloxacin Ciprofloxacin may increase clozapine serum levels
Citalopram The antidepressant increases the effect of clozapine
Clobazam Increased risk of toxicity
Clonazepam Increased risk of toxicity
Clorazepate Increased risk of toxicity
Diazepam Increased risk of toxicity
Donepezil Possible antagonism of action
Erythromycin Erythromycin increases the effect of clozapine
Estazolam Increased risk of toxicity
Ethotoin Hydantoin decreases the effect of clozapine
Fluoxetine The antidepressant increases the effect of clozapine
Flurazepam Increased risk of toxicity
Fluvoxamine The antidepressant increases the effect of clozapine
Fosphenytoin Hydantoin decreases the effect of clozapine
Galantamine Possible antagonism of action
Halazepam Increased risk of toxicity
Haloperidol Increases the effect and toxicity of haloperidol
Josamycin Erythromycin increases the effect of clozapine
Lamotrigine Lamotrigine increases the effect and toxicity of clozapine
Lisinopril Lisinopril increases the effect and toxicity of clozapine
Lorazepam Increased risk of toxicity
Mephenytoin Hydantoin decreases the effect of clozapine
Midazolam Increased risk of toxicity
Modafinil Modafinil increases the effect and toxicity of clozapine
Oxazepam Increased risk of toxicity
Norfloxacin Ciprofloxacin may increase clozapine serum levels
Phenytoin Hydantoin decreases the effect of clozapine
Temazepam Increased risk of toxicity
Triazolam Increased risk of toxicity
Rifabutin Rifabutin decreases the effect of clozapine
Rifampin Rifampin decreases the effect of clozapine
Ritonavir Ritonavir increases the effect and toxicity of clozapine
Rivastigmine Possible antagonism of action
Sertraline The antidepressant increases the effect of clozapine
Bromazepam Increased risk of toxicity
Cinolazepam Increased risk of toxicity
Flunitrazepam Increased risk of toxicity
Ketazolam Increased risk of toxicity
Nitrazepam Increased risk of toxicity
Prazepam Increased risk of toxicity
Quazepam Increased risk of toxicity

Clozaril Food Interactions:

Take without regard to meals.
Avoid alcohol.
Limit caffeine intake (may reduce clozapine matabolism).

Clozaril Generic Name:

Synonyms:

  • Clozapin

Drug Type:

Small Molecule; Approved

Absorption:

Rapid and almost complete

Toxicity (Overdose):

Not Available

Protein Binding:

97% (bound to serum proteins)

Biotransformation:

Hepatic

Half Life:

8 hours (range 4-12 hours)

Dosage Forms of Clozaril:

Tablet Oral

Chemical IUPAC Name:

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[c][1,5]benzodiazepine

Organisms Affected:

Humans and other mammals

Clozaril to general, pharmacology

General, pharmacology..