No untoward clinical manifestations have been observed in limited experience with patients in whom PRIMACOR was
used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin;
isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril;
heparin, warfarin, diazepam, insulin; and potassium supplements.
There is an immediate chemical interaction which is evidenced by the formation of a precipitate when furosemide is
injected into an intravenous line of an infusion of PRIMACOR. Therefore, furosemide should not be administered in
intravenous lines containing PRIMACOR.