Corotrope - General Information:A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase activity in myocardium and vascular smooth muscle. Corotrope is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone. [PubChem]
Other Brand Names containing Milrinone
Corotrope - Pharmacology:
Corotrope inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Corotrope also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
Corotrope for patients
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No untoward clinical manifestations have been observed in limited experience with patients in whom PRIMACOR was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements.
There is an immediate chemical interaction which is evidenced by the formation of a precipitate when furosemide is injected into an intravenous line of an infusion of PRIMACOR. Therefore, furosemide should not be administered in intravenous lines containing PRIMACOR.
PRIMACOR is contraindicated in patients who are hypersensitive to it.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..