Cyclobenz is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenz acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing by only one double bond.

Medicinal name:
  • Cyclobenzaprine hydrochloride 5 MG Oral Tablet
  • Cyclobenzaprine hydrochloride 10 MG Oral Tablet
  • Cyclobenzaprine hydrochloride 7.5 MG Oral Tablet

Cyclobenz - Pharmacology:

Like other tricyclic antidepressants, cyclobenzaprine exhibits anticholinergic activity, potentiation of norepinephrine, and antagonism of reserpine. Cyclobenz does not directly act on the neuromuscular junction or the muscle but relieves muscle spasms through a central action, possibly at the brain stem level. Cyclobenz binds to the serotonin receptor and is considered a 5-HT2 receptor antagonist that reduces muscle tone by decreasing the activity of descending serotonergic neurons.

Cyclobenz for patients

FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.

Cyclobenz Interactions

FLEXERIL may have life-threatening interactions with MAO inhibitors.

FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.

Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting compounds.

Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol.


Cyclobenz Contraindications

Hypersensitivity to any component of this product.

Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs.

Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure.


Manufacturers name:

  • Aurobindo Pharma Limited
  • Lake Erie Medical DBA Quality Care Product LLC
  • Amneal Pharmaceuticals
  • PD-Rx Pharmaceuticals, Inc
  • Bryant Ranch Prepack
  • MedVantx, Inc
  • RedPharm Drug Inc
  • Pharmaceutica North America, Inc
  • Blenheim Pharmacal, Inc
  • Glenmark Generics Inc, USA
  • Mylan Pharmaceuticals Inc
  • Unit Dose Services
  • Liberty Pharmaceuticals, Inc
  • Physicians Total Care, Inc
  • Watson Laboratories, Inc
  • Northwind Pharmaceuticals, LLC
  • Lake Erie Medical DBA Quality Care Products LLC
  • Camber Pharmaceuticals
  • Cardinal Health
  • McKesson Packaging Services Business Unit of McKesson Corporation
  • American Health Packaging
  • Aidarex Pharmaceuticals LLC
  • Rebel Distributors
  • Rebel Distributors Corp
  • Keltman Pharmaceuticals Inc
  • Preferred Pharmaceuticals, Inc
  • RxChange Co
  • Sandoz Inc
  • State of Florida DOH Central Pharmacy
  • Ranbaxy Pharmaceuticals Inc
  • KVK-TECH, Inc
  • Legacy Pharmaceutical Packaging
  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • Qualitest Pharmaceuticals
  • AvPAK
  • Proficient Rx LP
  • Breckenridge Pharmaceutical, Inc
  • HJ Harkins Company, Inc
  • Mylan Institutional Inc
  • Northwind Pharmaceuticals
  • McKesson Contract Packaging
  • Mutual Pharmaceutical
  • Dispensing Solutions, Inc
  • Golden State Medical Supply, Inc
  • NCS HealthCare of KY, Inc dba Vangard Labs
  • Clinical Solutions Wholesale
  • ReadyMeds
  • Major Pharmaceuticals
  • McKesson Packaging Services a business unit of McKesson Corporation
  • KLE 2, Inc
  • Aphena Pharma Solutions - Tennessee, LLC
  • Pliva Inc
  • SA3, LLC
  • Contract Pharmacy Services-PA
  • New Horizon Rx Group, LLC

Generic name, Overdose, Half Life Cyclobenz, Food Interactions, Chemical, etc..

Cyclobenz see also

Brand Names containing Cyclobenzaprine