Cytoxan Indication:

For management of malignant lymphomas, multiple myeloma,leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma and carcinoma of the breast

Cytoxan Mechanism Of Action:

Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

Cytoxan Drug Interactions:

Anisindione Increases the anticoagulant effect
Dicumarol Increases the anticoagulant effect
Acenocoumarol Increases the anticoagulant effect
Warfarin Increases the anticoagulant effect
Digoxin The antineoplasic agent decreases the effect of digoxin
Fluconazole Fluconazole reduces metabolism and clearance of cyclophosphamide
Pentostatin Increased toxicity of cyclophosphamide
Succinylcholine The agent increases the effect of succinylcholine

Cytoxan Food Interactions:

Take with food to reduce irritation.
Drink liberally- 2 to 3 liters/day.

Cytoxan Generic Name:

Synonyms:

  • Not Available

Drug Type:

Small Molecule; Approved

Absorption:

90-100%

Toxicity (Overdose):

infection, myelosuppression, and cardiac toxicity

Protein Binding:

>60%

Biotransformation:

hepatic

Half Life:

3-12 hours

Dosage Forms of Cytoxan:

Solution Intravenous
Powder, for solution Intravenous
Tablet Oral

Chemical IUPAC Name:

N,N-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine

Organisms Affected:

Humans and other mammals

Cytoxan to general, pharmacology

General, pharmacology..
Cancer