Decadron Indication:

Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.

Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.

Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus

Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy

Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps

Decadron Mechanism Of Action:

Decadron is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. This results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Decadron Drug Interactions:

Ambenonium The corticosteroid decreases the effect of anticholinesterases
Aminoglutethimide Aminogluthetimide decreases the effect of dexamethasone
Amobarbital The barbiturate decreases the effect of the corticosteroid
Anisindione The corticosteroid alters the anticoagulant effect
Aprepitant Aprepitant increases the effect and toxicity of dexamethasone
Aprobarbital The barbiturate decreases the effect of the corticosteroid
Aspirin The corticosteroid decreases the effect of salicylates
Butabarbital The barbiturate decreases the effect of the corticosteroid
Butalbital The barbiturate decreases the effect of the corticosteroid
Butethal The barbiturate decreases the effect of the corticosteroid
Dicumarol The corticosteroid alters the anticoagulant effect
Dihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroid
Edrophonium The corticosteroid decreases the effect of anticholinesterases
Ethotoin The enzyme inducer decreases the effect of the corticosteroid
Fosphenytoin The enzyme inducer decreases the effect of the corticosteroid
Heptabarbital The barbiturate decreases the effect of the corticosteroid
Hexobarbital The barbiturate decreases the effect of the corticosteroid
Imatinib Decreases levels of imatinib
Mephenytoin The enzyme inducer decreases the effect of the corticosteroid
Methohexital The barbiturate decreases the effect of the corticosteroid
Methylphenobarbital The barbiturate decreases the effect of the corticosteroid
Midodrine Increased arterial pressure
Neostigmine The corticosteroid decreases the effect of anticholinesterases
Pentobarbital The barbiturate decreases the effect of the corticosteroid
Phenobarbital The barbiturate decreases the effect of the corticosteroid
Phenytoin The enzyme inducer decreases the effect of the corticosteroid
Primidone The barbiturate decreases the effect of the corticosteroid
Pyridostigmine The corticosteroid decreases the effect of anticholinesterases
Quinidine barbiturate The barbiturate decreases the effect of the corticosteroid
Rifampin The enzyme inducer decreases the effect of the corticosteroid
Secobarbital The barbiturate decreases the effect of the corticosteroid
Sunitinib Possible decrease in sunitinib levels
Talbutal The barbiturate decreases the effect of the corticosteroid
Warfarin The corticosteroid alters the anticoagulant effect
Bismuth The corticosteroid decreases the effect of salicylates
Acenocoumarol The corticosteroid alters the anticoagulant effect
Salicylate-magnesium The corticosteroid decreases the effect of salicylates
Salsalate The corticosteroid decreases the effect of salicylates

Decadron Food Interactions:

Avoid alcohol.
Take with food to reduce irritation.
Avoid taking with grapefruit juice.

Decadron Generic Name:

Synonyms:

  • Desametasone [Dcit]
  • Desametasone
  • Desamethasone
  • DEX
  • Dexametasona [Inn-Spanish]
  • Dexamethasone Acetate
  • Dexamethasone Alcohol
  • Dexamethasone Base
  • Dexamethasone Sodium Phosphate
  • Dexamethasonum [Inn-Latin]
  • Dexamethazone
  • DXM
  • Dxms
  • Fluormethylprednisolone

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

80-90%

Toxicity (Overdose):

Oral, rat LD50: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.

Protein Binding:

70%

Biotransformation:

Hepatic.

Half Life:

36-54 hours

Dosage Forms of Decadron:

Solution Intravenous
Liquid Intravenous
Tablet Oral
Solution Ophthalmic
Solution / drops Ophthalmic
Liquid Oral
Elixir Oral
Ointment Ophthalmic
Liquid Intramuscular

Chemical IUPAC Name:

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Organisms Affected:

Humans and other mammals

Decadron to general, pharmacology

General, pharmacology..