Depakote Indication:

For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache.

Depakote Mechanism Of Action:

Divalproex binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

Depakote Drug Interactions:

Amobarbital Valproic acid increases the effect of barbiturate
Aprobarbital Valproic acid increases the effect of barbiturate
Aspirin The salicylate increases the effect of valproic acid
Bismuth Subsalicylate The salicylate increases the effect of valproic acid
Butabarbital Valproic acid increases the effect of barbiturate
Butalbital Valproic acid increases the effect of barbiturate
Butethal Valproic acid increases the effect of barbiturate
Carbamazepine Carbamazepine decreases the effect of valproic acid
Cholestyramine Cholestyramine decreases the levels of valproate
Cisplatin Possible decrease of anticonvulsant levels
Dihydroquinidine barbiturate Valproic acid increases the effect of barbiturate
Erythromycin Erythromycin increases the effect of valproic acid
Ethotoin Valproate increases the effect of hydantoin
Felbamate Felbamate increases the effect of valproate
Fosphenytoin Valproate increases the effect of hydantoin
Heptabarbital Valproic acid increases the effect of barbiturate
Hexobarbital Valproic acid increases the effect of barbiturate
Josamycin Erythromycin increases the effect of valproic acid
Lamotrigine Valproic acid increases the effect of lamotrigine
Mephenytoin Valproate increases the effect of hydantoin
Meropenem Decreased plasma antiepileptic levels
Methohexital Valproic acid increases the effect of barbiturate
Methylphenobarbital Valproic acid increases the effect of barbiturate
Nimodipine Valproic acid increases the effect of nimodipine
Pentobarbital Valproic acid increases the effect of barbiturate
Phenobarbital Valproic acid increases the effect of barbiturate
Phenytoin Valproate increases the effect of hydantoin
Primidone Valproic acid increases the effect of barbiturate
Quinidine barbiturate Valproic acid increases the effect of barbiturate
Risperidone Risperidone increases the effect and toxicity of valproic acid
Ritonavir Possible decrease of valproate levels
Salicylate-magnesium The salicylate increases the effect of valproic acid
Salicylate-sodium The salicylate increases the effect of valproic acid
Salsalate The salicylate increases the effect of valproic acid
Trisalicylate-choline The salicylate increases the effect of valproic acid
Secobarbital Valproic acid increases the effect of barbiturate
Talbutal Valproic acid increases the effect of barbiturate

Depakote Food Interactions:

Take with food to reduce irritation.
Food slows the rate of absorption but the extent of absorption is not affected.

Depakote Generic Name:

Synonyms:

  • Divalproex sodium
  • Valproate semisodium

Drug Type:

Small Molecule; Approved

Absorption:

Rapid absorption from gastrointestinal tract.

Toxicity (Overdose):

Overdosage with divalproex may result in somnolence,heart block,and deep coma. Fatalities have been reported; however patients have recovered from divalproex levels as high as 2120 µg/mL.

Protein Binding:

80-90%

Biotransformation:

Divalproex is metabolized almost entirely by the liver. Mitochondrial ß-oxidation is the other major metabolic pathway, typically accounting for over 40% of the dose.

Half Life:

9-16 hours

Dosage Forms of Depakote:

Tablet, delayed release Oral

Chemical IUPAC Name:

sodium; 2-propylpentanoate; 2-propylpentanoic acid

Organisms Affected:

Humans and other mammals

Depakote to general, pharmacology

General, pharmacology..
General health