Detrol

Detrol is an antimuscarinic drug that is used to treat urinary incontinence. Detrol acts on M2 and M3 subtypes of muscarinic receptors.

Medicinal name:
  • 24 HR tolterodine tartrate 4 MG Extended Release Oral Capsule [Detrol]
  • Tolterodine tartrate 2 MG Oral Tablet [Detrol]
  • 24 HR tolterodine tartrate 2 MG Extended Release Oral Capsule [Detrol]
  • Tolterodine tartrate 1 MG Oral Tablet [Detrol]

Detrol - Pharmacology:

Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, act as competitive antagonists at muscarinic receptors. This results in inhibition of bladder contraction, decrease in detrusor pressure, and an incomplete emptying of the bladder.

Detrol mini report

Detrol NDA
NDA - A product marketed under an approved New Drug Application
Detrol TABLET, FILM COATED
TABLET, FILM COATED
Detrol HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Detrol global name
tolterodine tartrate
Start - Stop data
START DATA:
1998-Mar-25
Start - Stop data
STOP DATA
not occurred

Detrol Interactions

CYP3A4 Inhibitors: Ketoconazole, an inhibitor of the drug metabolizing enzyme CYP3A4, significantly increased plasma concentrations of tolterodine when coadministered to subjects who were poor metabolizers (see CLINICAL PHARMACOLOGY, Variability in Metabolism and Drug-Drug Interactions). For patients receiving ketoconazole or other potent CYP3A4 inhibitors such as other azole antifungals (eg, itraconazole, miconazole) or macrolide antibiotics (eg, erythromycin, clarithromycin) or cyclosporine or vinblastine, the recommended dose of DETROL LA is 2 mg daily.

Drug-Laboratory-Test Interactions

Interactions between tolterodine and laboratory tests have not been studied.

Detrol Contraindications

DETROL LA Capsules are contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma. DETROL LA is also contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.

Manufacturers name:

  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • STAT RX USA LLC
  • Physicians Total Care, Inc
  • PD-Rx Pharmaceuticals, Inc
  • Cardinal Health
  • Pharmacia and Upjohn Company

Generic name, Overdose, Half Life Detrol, Food Interactions, Chemical, etc..

Detrol see also FDA report Saw Palmetto

Brand Names containing Tolterodine
General health