Diamox Indication:

For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Diamox Mechanism Of Action:

The anticonvulsant activity of Diamox may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.

Diamox Drug Interactions:

Aspirin The salicylate at high dose increases the effect of the carbonic anhydrase inhibitors
Salicyclic acid The salicylate at high dose increases the effect of the carbonic anhydrase inhibitors
Cyclosporine Diamox increases the effect of toxicity of cyclosporine
Memantine Possible increased levels of memantine
Bismuth Subsalicylate The salicylate at high dose increases the effect of the carbonic anhydrase inhibitors

Diamox Food Interactions:

Take with food; at least 6 hours before bedtime.
Drink plenty of liquids.

Diamox Generic Name:

Synonyms:

  • Acetamidothiadiazolesulfonamide
  • Acetazolamid
  • Acetazolamide Sodium
  • Acetazolamine
  • Acetazoleamide
  • Acetozalamide
  • Carbonic Anhydrase Inhibitor 6063

Drug Type:

Small Molecule; Approved

Absorption:

Not Available

Toxicity (Overdose):

Not Available

Protein Binding:

98%

Biotransformation:

Not Available

Half Life:

3 to 9 hours

Dosage Forms of Diamox:

Tablet Oral

Chemical IUPAC Name:

N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

Organisms Affected:

Humans and other mammals

Diamox to general, pharmacology

General, pharmacology..