Ditropan Indication:

For the treatment of overactive bladder.

Ditropan Mechanism Of Action:

Ditropan exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. No blocking effects occur at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects).

Ditropan Drug Interactions:

Carbamazepine Ditropan may cause carbamazepine toxicity
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Rivastigmine Possible antagonism of action

Ditropan Food Interactions:

Avoid alcohol.
Take with food.

Ditropan Generic Name:

Synonyms:

  • Oxibutinina [Inn-Spanish]
  • Oxibutyninum
  • Oxybutynin Base
  • Oxybutynin Chloride
  • Oxybutynin Hydrochloride
  • Oxybutynine [Inn-French]
  • Oxybutyninum [Inn-Latin]
  • Oxybutinin

Drug Type:

Small Molecule; Approved

Absorption:

Rapidly absorbed from gastrointestinal tract.

Toxicity (Overdose):

LD50=1220 mg/kg (Orally in rats, Goldenthal)

Protein Binding:

91%-93%

Biotransformation:

Hepatic, primarily by CYP3A4

Half Life:

12.4-13.2 hours

Dosage Forms of Ditropan:

Tablet, extended release Oral
Tablet Oral
Patch Transdermal
Syrup Oral

Chemical IUPAC Name:

4-diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Organisms Affected:

Humans and other mammals

Ditropan to general, pharmacology

General, pharmacology..
General health