Estrace Indication:

For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Estrace Mechanism Of Action:

Estrace enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

Estrace Drug Interactions:

Amobarbital The enzyme inducer decreases the effect of hormones
Aprobarbital The enzyme inducer decreases the effect of hormones
Butabarbital The enzyme inducer decreases the effect of hormones
Butalbital The enzyme inducer decreases the effect of hormones
Butethal The enzyme inducer decreases the effect of hormones
Ethotoin The enzyme inducer decreases the effect of hormones
Fosphenytoin The enzyme inducer decreases the effect of hormones
Griseofulvin The enzyme inducer decreases the effect of hormones
Heptabarbital The enzyme inducer decreases the effect of hormones
Hexobarbital The enzyme inducer decreases the effect of hormones
Mephenytoin The enzyme inducer decreases the effect of hormones
Methohexital The enzyme inducer decreases the effect of hormones
Methylphenobarbital The enzyme inducer decreases the effect of hormones
Pentobarbital The enzyme inducer decreases the effect of hormones
Phenobarbital The enzyme inducer decreases the effect of hormones
Phenytoin The enzyme inducer decreases the effect of hormones
Prednisolone The estrogenic agent increases the effect of corticosteroid
Prednisone The estrogenic agent increases the effect of corticosteroid
Primidone The enzyme inducer decreases the effect of hormones
Secobarbital The enzyme inducer decreases the effect of hormones
Talbutal The enzyme inducer decreases the effect of hormones
Raloxifene Association not recommended
Ursodeoxycholic acid Estrogens decreases the effect of ursodiol

Estrace Food Interactions:

Take with food to decrease nausea.

Estrace Generic Name:

Synonyms:

  • D-Estradiol
  • D-Oestradiol
  • Estradiol-17beta
  • Estradiol Valerate
  • Estradiol Cypionate
  • Dihydroxyestrin
  • Dihydroxyoestrin
  • Dihydroxyesterin
  • Dihydrofollicular Hormone
  • Dihydrofolliculin
  • Cis-Estradiol
  • Cis-Oestradiol
  • Beta-Estradiol

Drug Type:

Small Molecule; Approved

Absorption:

43%

Toxicity (Overdose):

Can cause nausea and vomiting, and withdrawal bleeding may occur in females.

Protein Binding:

>95%

Biotransformation:

Exogenous estrogens are metabolized using the same mechanism as endogenous estrogens. Estrogens are partially metabolized by cytochrome P450.

Half Life:

36 hours

Dosage Forms of Estrace:

Ring Intravaginal
Gel Transdermal
Tablet Oral
Tablet Intravaginal
Disc Transdermal
Patch Transdermal
Liquid Intramuscular

Chemical IUPAC Name:

(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Organisms Affected:

Humans and other mammals

Estrace to general, pharmacology

General, pharmacology..