Excedrin - General Information:Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. [PubChem]
Other Brand Names containing Acetaminophen
Excedrin - Pharmacology:
Excedrin is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1 and COX-2, enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works.
Excedrin for patients
Do not use the maximum dosage of this product for more than 10 days except under the advice and supervision of a physician. Do not take the product for pain for more than 10 days, or for fever for more than 3 days unless directed by a physician. If pain or fever persists or gets worse, if new symptoms occur, or if redness or swelling is present, consult a physician because these could be signs of a serious condition. Do not use with other products containing acetaminophen.
Do not use if carton is opened. Keep this and all medication out of The reach of children. As with any drug, if you are pregnant or nursing A baby, seek the advice of a health professional before using this product. In the case of accidental overdose, contact a doctor or a poison control Center immediately. Prompt medical attention is critical for adults as Well as for children even if you do not notice any signs or symptoms.
Data is temporarily not available
Acetaminophen should not be administered to patients who have previously exhibited hypersensitivity to it.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..