Excedrin

Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. .
[PubChem].

Medicinal name:
  • Acetaminophen 250 MG / Aspirin 250 MG / Caffeine 65 MG Oral Tablet [Excedrin]
  • Acetaminophen 500 MG / Caffeine 65 MG Oral Tablet [Excedrin Tension Headache]
  • Acetaminophen 250 MG / Aspirin 250 MG / Diphenhydramine Citrate 38 MG Oral Tablet [Excedrin PM Triple Action]
  • Acetaminophen 325 MG / Caffeine 65 MG Oral Tablet [Excedrin Mild Headache]
  • Acetaminophen 500 MG / Diphenhydramine Citrate 38 MG Oral Tablet [Excedrin PM]
  • Acetaminophen 250 MG / Aspirin 250 MG Oral Tablet [Excedrin Back & Body]

Excedrin - Pharmacology:

Excedrin is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1 and COX-2, enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works.

Excedrin mini report

Excedrin OTC MONOGRAPH FINAL
OTC MONOGRAPH FINAL - A product marketed pursuant to a final OTC Drug Monograph
Excedrin NDA
NDA - A product marketed under an approved New Drug Application
Excedrin OTC MONOGRAPH NOT FINAL
OTC MONOGRAPH NOT FINAL -
Excedrin ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Excedrin CAPSULE, GELATIN COATED
CAPSULE, GELATIN COATED
Excedrin TABLET
TABLET
Excedrin TABLET, COATED
TABLET, COATED
Excedrin TABLET, FILM COATED
TABLET, FILM COATED
Excedrin HUMAN OTC DRUG
HUMAN OTC DRUG
Excedrin global name
Acetaminophen, Asprin (NSAID) and Caffine
Excedrin global name
Acetaminophen, Diphenhydramine Citrate
Excedrin global name
Acetaminophen, Asprin, Caffeine
Excedrin global name
Acetaminophen, Aspirin (NSAID) and Caffeine
Excedrin global name
Acetaminophen, Aspirin and Caffeine
Excedrin global name
Acetaminophine, caffeine
Excedrin global name
Acetaminophen, Aspirin
Excedrin global name
Acetaminophen, Aspirin (NSAID), and Caffeine
Excedrin global name
Acetaminophen and Caffeine
Start - Stop data
START DATA:
2009-Dec-10
Start - Stop data
STOP DATA
not occurred

Excedrin for patients

Do not use the maximum dosage of this product for more than 10 days except under the advice and supervision of a physician. Do not take the product for pain for more than 10 days, or for fever for more than 3 days unless directed by a physician. If pain or fever persists or gets worse, if new symptoms occur, or if redness or swelling is present, consult a physician because these could be signs of a serious condition. Do not use with other products containing acetaminophen.

Do not use if carton is opened. Keep this and all medication out of The reach of children. As with any drug, if you are pregnant or nursing A baby, seek the advice of a health professional before using this product. In the case of accidental overdose, contact a doctor or a poison control Center immediately. Prompt medical attention is critical for adults as Well as for children even if you do not notice any signs or symptoms.

Excedrin Interactions

Data is temporarily not available

Excedrin Contraindications

Excedrin should not be administered to patients who have previously exhibited hypersensitivity to it.

Manufacturers name:

  • Novartis Consumer Health, Inc
  • State of Florida DOH Central Pharmacy
  • Lil Drug Store Products, Inc

Generic name, Overdose, Half Life Excedrin, Food Interactions, Chemical, etc..

Excedrin see also FDA report