Famciclovir

Famciclovir is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).

Medicinal name:
  • Famciclovir 125 MG Oral Tablet
  • Famciclovir 500 MG Oral Tablet
  • Famciclovir 250 MG Oral Tablet

Famciclovir - Pharmacology:

Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted to penciclovir triphosphate by cellular kinases. In vitro studies demonstrate that penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.

Famciclovir mini report

Famciclovir ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Famciclovir TABLET
TABLET
Famciclovir TABLET, FILM COATED
TABLET, FILM COATED
Famciclovir HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Famciclovir global name
Famciclovir
Famciclovir global name
famciclovir
Famciclovir global name
FAMCICLOVIR
Start - Stop data
START DATA:
2011-Jan-03
Start - Stop data
STOP DATA
not occurred

Famciclovir for patients

Patients should be informed that Famvir is not a cure for genital herpes. There are no data evaluating whether Famvir will prevent transmission of infection to others. As genital herpes is a sexually transmitted disease, patients should avoid contact with lesions or intercourse when lesions and/or symptoms are present to avoid infecting partners. Genital herpes can also be transmitted in the absence of symptoms through asymptomatic viral shedding. If medical management of recurrent episodes is indicated, patients should be advised to initiate therapy at the first sign or symptom.

Famciclovir Interactions

Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.

The conversion of 6-deoxy penciclovir to penciclovir is catalyzed by aldehyde oxidase. Interactions with other drugs metabolized by this enzyme could potentially occur.

Famciclovir Contraindications

Famvir (famciclovir) is contraindicated in patients with known hypersensitivity to the product, its components, and Denavir® (penciclovir cream).

Manufacturers name:

  • Mylan Pharmaceuticals Inc
  • AvPAK
  • Northstar Rx LLC
  • Greenstone LLC
  • Aurobindo Pharma Limited
  • AvKARE, Inc
  • American Health Packaging
  • Physicians Total Care, Inc
  • Sandoz Inc
  • PD-Rx Pharmaceuticals, Inc
  • Roxane Laboratories, Inc
  • Macleods Pharmaceuticals Limited
  • Watson Laboratories, Inc
  • Camber Pharmaceuticals, Inc
  • Teva Pharmaceuticals USA Inc
  • Apotex Corp
  • Golden State Medical Supply, Inc

Generic name, Overdose, Half Life Famciclovir, Food Interactions, Chemical, etc..

Famciclovir see also FDA report Reishi Mushroom

Brand Names containing Famciclovir
Anti Viral