Flonase

Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.

Flonase - Pharmacology:

Binds to the glucocorticoid receptor. Unbound corticosteroids cross the membranes of cells such as mast cells and eosinophils, binding with high affinity to glucocorticoid receptors (GR). The results include alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. In the management of asthma, the glucocorticoid receptor complexes down-regulates proinflammatory mediators such as interleukin-(IL)-1, 3, and 5, and up-regulates anti-inflammatory mediators such as IkappaB [inhibitory molecule for nuclear factor kappaB1], IL-10, and IL-12. The antiinflammatory actions of corticosteroids are also thought to involve release of cytosolic phospholipase A2 which controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Flonase mini report

Flonase NDA
NDA - A product marketed under an approved New Drug Application
Flonase SPRAY, METERED
SPRAY, METERED
Flonase HUMAN OTC DRUG
HUMAN OTC DRUG
Flonase HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Flonase global name
fluticasone propionate
Flonase global name
Fluticasone Propionate
Start - Stop data
START DATA:
2014-Dec-04
Start - Stop data
STOP DATA
not occurred

Flonase Interactions

No Information Provided.

Flonase Contraindications

CUTIVATE Cream is contraindicated in those patients with a history of hypersensitivity to any of the components in the preparation.

Generic name, Overdose, Half Life Flonase, Food Interactions, Chemical, etc..

Flonase see also FDA report Stinging Nettle

Allergy
Brand Names containing Fluticasone Propionate