Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including:
anticonvulsant medications (such as phenytoin, and primidone)
metformin (sometimes prescribed to control blood sugar in type 2 diabetes)
sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis)
triamterene (a diuretic)
There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.
It is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.