Furacillin - General Information:

A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Furacillin has also been administered orally in the treatment of trypanosomiasis. [PubChem]

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Furacillin - Pharmacology:

The exact mechanism of action is unknown. Furacillin inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase.

Furacillin for patients

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Furacillin Interactions

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Furacillin Contraindications

  1. Renal function impairment: polyethylene glycols in the base of the topical solution and the soluble dressing may be absorbed through denuded skin and may not be excreted normally, which may lead to increased blood urea nitrogen (BUN), anion gap, and metabolic acidosis.
  2. Sensitivity to nitrofurazone or other components of the formulation.

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