Garamycin

A complex of three different closely related aminoglycoside sulfates, Garamycins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (genetic translation). .
[PubChem].

Garamycin - Pharmacology:

Aminoglycosides like gentamicin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically gentamicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

Garamycin mini report

Garamycin ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Garamycin OINTMENT
OINTMENT
Garamycin SOLUTION/ DROPS
SOLUTION/ DROPS
Garamycin HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Start - Stop data
START DATA:
2010-Oct-08
Start - Stop data
STOP DATA
not occurred

Garamycin Interactions

No information provided.

Garamycin Contraindications

Hypersensitivity to gentamicin is a contraindication to its use. A history of hypersensitivity or serious toxic reactions to other aminoglycosides may contraindicate use of gentamicin because of the known cross-sensitivity of patients to drugs in this class.

Generic name, Overdose, Half Life Garamycin, Food Interactions, Chemical, etc..

Garamycin see also FDA report

Brand Names containing Gentamicin