Gastron - General Information:Gastron is a synthetic antispasmodic. Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. Gastron is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems (irritable bowel syndrome), pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems (reflex neurogenic bladder in children).
Other Brand Names containing Methantheline
Gastron - Pharmacology:
Gastron inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder.
Gastron for patients
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This drug may interact with the following: antacids, diarrhea medicine containing kaolin or attapulgite, ketoconazole (using these medicines with an anticholinergic may lessen the effects of the anticholinergic), central nervous system (CNS) depressants (taking scopolamine with CNS depressants may increase the effects of either medicine), other anticholinergics (medicine for abdominal or stomach spasms or cramps), tricyclic antidepressants (taking anticholinergics with tricyclic antidepressants or other anticholinergics may cause an increase in the effects of the anticholinergic), and potassium chloride (using this medicine with an anticholinergic may make gastrointestinal problems caused by potassium worse).
Contraindicated in the following: hypersensitivity to anticholinergics, narrow-angle glaucoma, GI obstruction, myasthenia gravis, paralytic ileus, GI atony, and toxic megacolon.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..