Gen-Fibro - General Information:

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gen-Fibro increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]

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Gen-Fibro - Pharmacology:

Gen-Fibro increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gen-Fibro also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.

Gen-Fibro for patients

Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.

Gen-Fibro Interactions

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 Clinical Laboratory
 
increased creatine
positive antinuclear
 
phosphokinase
antibody
 
increased bilirubin
 
 
increased liver
 
 
transaminases (AST
 
 
(SGOT), ALT (SGPT)
 
 
increased alkaline
 
 
phophatase
 
 Hematopoietic
anemia
thrombocytopenia
 
leukopenia
 
 
bone marrow hypoplasia
 
 
eosinophilia
 
 Immunologic
angioedema
anaphylaxis
 
laryngeal edema
Lupus-like syndrome
 
urticaria
vasculitis
 Integumentary
exfoliative dermatitis
alopecia
 
rash
 
 
dermatitis
 
 
pruritus
 


Gen-Fibro Contraindications

1. Combination therapy of LOPID with cerivastatin due to the increased risk of myopathy and rhabdomyolysis.

2. Hepatic or severe renal dysfunction, including primary biliary cirrhosis.

3. Preexisting gallbladder disease.

4. Hypersensitivity to gemfibrozil.

Gen-Fibro more info

Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..
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