Store ethoxzolamide in a cool, dark area. Reconstituted solution must be used within 24 hours. Do not break, crush, or chew capsules. Take with food if you experience nausea, but note that this may decrease the absorption of the drug. You may also need to take potassium supplements while on this drug as it can cause potassium deficiency. If you are using this drug as a diuretic, it should be taken in the morning to avoid sleep disturbance (frequent urination during the night). If you miss a dose, take as soon as possible but do not double up the dose. Notify your doctor if you experience sore throat, unusual bleeding, bruising, paresthesias, tremors, flank pain, or skin rash. Since this medication may cause drowsiness, avoid hazardous activities such as driving until you know how you will react to the drug.
Ethoxzolamide may increase the action of tricyclics, amphetamines, procainamide, and quinidine. It may increase excretion of barbiturates, lithium, and ASA and may also increase the toxicity of salicylates. Coadministration of ethoxzolamide with other diuretics, amphotericin B, and corticosteroids may cause hypokalemia.
Ethoxzolamide is contraindicated in patients with severe hypersensitivity to sulfonamides, severe hepatic disease, severe renal disease, electrolytic imbalances such as hyponatremia and hypokalemia, hyperchloremic acidosis, Addisons disease, and long-term use in narrow-angle glaucoma.