Glimicron - General Information:An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion. [PubChem]
Other Brand Names containing Gliclazide
Glimicron - Pharmacology:
Glimicron binds to the beta cell sulfonyl urea receptor (SUR1). This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the beta cells. This opens voltage-dependent calcium channels in the beta cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..