Glimicron - General Information:

An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion. [PubChem]

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Glimicron - Pharmacology:

Glimicron binds to the beta cell sulfonyl urea receptor (SUR1). This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the beta cells. This opens voltage-dependent calcium channels in the beta cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.

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