An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. .

Hemel - Pharmacology:

The precise mechanism by which altretamine exerts its cytotoxic effect is unknown.

Hemel Interactions

Concurrent administration of HEXALEN and antidepressants of the MAO inhibitor class may cause severe orthostatic hypotension.Cimetidine, an inhibitor of microsomal drug metabolism, increased altretamines half-life and toxicity in a rat model.

Data from a randomized trial of HEXALEN and cisplatin plus or minus pyridoxine in ovarian cancer indicated that pyridoxine significantly reduced neurotoxicity; however, it adversely affected response duration suggesting that pyridoxine should not be administered with HEXALEN and/or cisplatin.1

Hemel Contraindications

HEXALEN is contraindicated in patients who have shown hypersensitivity to it. HEXALEN should not be employed in patients with preexisting severe bone marrow depression or severe neurologic toxicity. HEXALEN has been administered safely, however, to patients heavily pretreated with cisplatin and/or alkylating agents, including patients with preexisting cisplatin neuropathies. Careful monitoring of neurologic function in these patients is essential.

Generic name, Overdose, Half Life Hemel, Food Interactions, Chemical, etc..

Hemel see also

Brand Names containing Altretamine