Herceptin

A recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein. Produced in CHO cell culture.

Herceptin - Pharmacology:

Herceptin binds to the HER2 (or c-erbB2) proto-oncogene, an EGF receptor-like protein found on 20-30% of breast cancer cells. The binding leads to antibody mediated (complement mediated) killing of the HER2 positive cells.

Herceptin mini report

Herceptin BLA
BLA - A product marketed under an approved Biologic License Application
Herceptin HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Start - Stop data
START DATA:
1998-Sep-25
Start - Stop data
STOP DATA
not occurred

Herceptin Interactions

There have been no formal drug interaction studies performed with HERCEPTIN in humans. Administration of paclitaxel in combination with HERCEPTIN resulted in a two-fold decrease in HERCEPTIN clearance in a non-human primate study and in a 1.5-fold increase in HERCEPTIN serum levels in clinical studies.

Herceptin Contraindications

None known.

Generic name, Overdose, Half Life Herceptin, Food Interactions, Chemical, etc..

Herceptin see also