Hydrea

An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. .
[PubChem].

Medicinal name:
  • Hydroxyurea 500 MG Oral Capsule [Hydrea]

Hydrea - Pharmacology:

Hydrea is converted to a free radical nitroxide (NO) in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active site of the M2 protein subunit of ribonucleotide reductase, inactivating the enzyme. The entire replicase complex, including ribonucleotide reductase, is inactivated and DNA synthesis is selectively inhibited, producing cell death in S phase and synchronization of the fraction of cells that survive. Repair of DNA damaged by chemicals or irradiation is also inhibited by hydroxyurea, offering potential synergy between hydroxyurea and radiation or alkylating agents. Hydrea also increases the level of fetal hemoglobin, leading to a reduction in the incidence of vasoocclusive crises in sickle cell anemia. Levels of fetal hemoglobin increase in response to activation of soluble guanylyl cyclase (sGC) by hydroxyurea-derived NO.

Hydrea mini report

Hydrea NDA
NDA - A product marketed under an approved New Drug Application
Hydrea HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Start - Stop data
START DATA:
2009-Jun-01
Start - Stop data
STOP DATA
not occurred

Hydrea for patients

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Hydrea Interactions

Prospective studies on the potential for hydroxyurea to interact with other drugs have not been performed.

Concurrent use of hydroxyurea and other myelosuppressive agents or radiation therapy may increase the likelihood of bone marrow depression or other adverse events.

Since hydroxyurea may raise the serum uric acid level, dosage adjustment of uricosuric medication may be necessary.

 

 

Hydrea Contraindications

Hydrea is contraindicated in patients with marked bone marrow depression, i.e., leukopenia (<2500 WBC) or thrombocytopenia (<100,000), or severe anemia.

HYDREA is contraindicated in patients who have demonstrated a previous hypersensitivity to hydroxyurea or any other component of its formulation.

Manufacturers name:

  • ER Squibb & Sons, LLC

Generic name, Overdose, Half Life Hydrea, Food Interactions, Chemical, etc..

Hydrea see also FDA report

Brand Names containing Hydroxyurea
Cancer