Imodium Indication:

For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.

Imodium Mechanism Of Action:

In vitro and animal studies show that Imodium acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Imodium inhibits peristaltic activity by a direct effect on the circular and longitudinal muscles of the intestinal wall. It is a non-selective calcium channel blocker and binds to opioid mu-receptors. Evidence also suggests that at higher concentrations it binds to NMDA receptors and to calmodulin.

Imodium Drug Interactions:

Not Available

Imodium Food Interactions:

Take without regard to meals. Increase liquid intake.

Imodium Generic Name:

Synonyms:

  • Not Available

Drug Type:

Small Molecule; Approved

Absorption:

Not significantly absorbed from the gut

Toxicity (Overdose):

Oral, mouse: LD50 = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.

Protein Binding:

97%

Biotransformation:

Hepatic

Half Life:

9.1 to 14.4 hours (average 10.8 hours)

Dosage Forms of Imodium:

Tablet Oral
Solution Oral

Chemical IUPAC Name:

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-di(phenyl)butanamide

Organisms Affected:

Humans and other mammals

Imodium to general, pharmacology

General, pharmacology..
Gastro Health