Imuran Indication:

For use as an adjunct in the prevention of rejection in renal homotransplantation. Also for the management of severe, active rheumatoid arthritis unresponsive to rest, aspirin or other nonsteroidal anti-inflammatory drugs, or to agents in the class of which gold is an example.

Imuran Mechanism Of Action:

Imuran antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. It may also interfere with cellular metabolism and inhibit mitosis. The mechanism of action of azathioprine in rheumatoid arthritis is not known but is most likely related to its immunosuppresive action.

Imuran Drug Interactions:

Allopurinol Allopurinol increases the effect of thiopurine
Anisindione The thiopurine decreases the anticoagulant effect
Atracurium The agent decreases the effect of the muscle relaxant
Dicumarol The thiopurine decreases the anticoagulant effect
Doxacurium The agent decreases the effect of the muscle relaxant
Gallamine Triethiodide The agent decreases the effect of the muscle relaxant
Mesalazine The 5-ASA derivative increases the toxicity of thiopurine
Metocurine The agent decreases the effect of the muscle relaxant
Mivacurium The agent decreases the effect of the muscle relaxant
Acenocoumarol The thiopurine decreases the anticoagulant effect
Olsalazine The 5-ASA derivative increases the toxicity of thiopurine
Pancuronium The agent decreases the effect of the muscle relaxant
Sulfasalazine The 5-ASA derivative increase the toxicity of thiopurine
Tubocurarine The agent decreases the effect of the muscle relaxant
Vecuronium The agent decreases the effect of the muscle relaxant
Warfarin The thiopurine decreases the anticoagulant effect

Imuran Food Interactions:

Take with food to reduce irritation.

Imuran Generic Name:

Synonyms:

  • Azathioprine Sodium
  • Azathioprin
  • Azothioprine
  • Azatioprin

Drug Type:

Small Molecule; Approved

Absorption:

Well absorbed following oral administration.

Toxicity (Overdose):

The oral LD50 for single doses of azathioprine in mice and rats are 2500 mg/kg and 400 mg/kg, respectively. Very large doses of this antimetabolite may lead to marrow hypoplasia, bleeding, infection, and death.

Protein Binding:

Azathioprine and the metabolite mercaptopurine are moderately bound to serum proteins (30%).

Biotransformation:

Primarily converted to the active metabolites 6-mercaptopurine and 6-thioinosinic acid.

Half Life:

Approximately 5 hours for the unchanged drug and its metabolites.

Dosage Forms of Imuran:

Powder, for solution Intravenous
Tablet Oral

Chemical IUPAC Name:

6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine

Organisms Affected:

Humans and other mammals

Imuran to general, pharmacology

General, pharmacology..
Pain Relief