Indocin Indication:

For moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis.

Indocin Mechanism Of Action:

Antiinflammatory effects of Indocin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

Indocin Drug Interactions:

Acebutolol Risk of inhibition of renal prostaglandins
Atenolol Risk of inhibition of renal prostaglandins
Betaxolol Risk of inhibition of renal prostaglandins
Bevantolol Risk of inhibition of renal prostaglandins
Bisoprolol Risk of inhibition of renal prostaglandins
Carteolol Risk of inhibition of renal prostaglandins
Carvedilol Risk of inhibition of renal prostaglandins
Methotrexate The NSAID increases the effect and toxicity of methotrexate
Diflunisal Diflunisal increases the effect and toxicity of indomethacin
Esmolol Risk of inhibition of renal prostaglandins
Labetalol Risk of inhibition of renal prostaglandins
Metoprolol Risk of inhibition of renal prostaglandins
Nadolol Risk of inhibition of renal prostaglandins
Losartan Indocin decreases the effect of losartan
Lithium The NSAID increases serum levels of lithium
Oxprenolol Risk of inhibition of renal prostaglandins
Penbutolol Risk of inhibition of renal prostaglandins
Pindolol Risk of inhibition of renal prostaglandins
Practolol Risk of inhibition of renal prostaglandins
Probenecid Probenecid increases the effect/toxicity of indomethacin
Sotalol Risk of inhibition of renal prostaglandins
Propranolol Risk of inhibition of renal prostaglandins
Timolol Risk of inhibition of renal prostaglandins
Warfarin The NSAID increases the anticoagulant effect
Acenocoumarol The NSAID increases the anticoagulant effect
Dicumarol The NSAID increases the anticoagulant effect
Anisindione The NSAID increases the anticoagulant effect
Torasemide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic
Bumetanide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic
Furosemide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic
Ethacrynic acid The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic
Cyclosporine Monitor for nephrotoxicity
Alendronate Increased risk of gastric toxicity
Triamterene Risk of acute renal impairment with this combination

Indocin Food Interactions:

Avoid alcohol.
Take with food or antacids to reduce irritation.

Indocin Generic Name:

Synonyms:

  • IMN
  • Indomethacinum
  • Indomethacine
  • Indometacyna
  • Indometacine
  • Indomethancin
  • Indomethazine
  • Indomethine
  • Indometicina

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

Bioavailability is approximately 100% following oral administration and 80–90% following rectal administration.

Toxicity (Overdose):

The following symptoms may be observed following overdosage: nausea, vomiting, intense headache, dizziness, mental confusion, disorientation, or lethargy. There have been reports of paresthesias, numbness, and convulsions. The oral LD50 of indomethacin in mice and rats (based on 14 day mortality response) was 50 and 12 mg/kg, respectively.

Protein Binding:

97%

Biotransformation:

Hepatic.

Half Life:

4.5 hours

Dosage Forms of Indocin:

Powder, for solution Intravenous
Suppository Rectal
Capsule Oral

Chemical IUPAC Name:

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Organisms Affected:

Humans and other mammals

Indocin to general, pharmacology

General, pharmacology..