Isotox - General Information:An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer. [PubChem]
Other Brand Names containing Lindane
Isotox - Pharmacology:
Isotox is an organochloride insecticide that exerts its parasiticidal action by being directly absorbed into the parasites (primarily lice, or scabies) and their ova. The gamma-aminobutyric acid (GABA(1)) receptor/chloride ionophore complex is the primary site of action for lindane, and other insecticides such as endosulfan, and fipronil. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system, convulsions, and death.
Isotox for patients
Oils may enhance absorption. Therefore, simultaneous use of creams, ointments or oils should be avoided.
Lindane Lotion is contraindicated for premature neonates because their skin may be more permeable than full term infants and their liver enzymes may not be sufficiently developed. It is also contraindicated for patients with Norwegian (crusted) scabies due to possible increased absorption. It is also contraindicated for patients with known seizure disorders and for individuals with a known sensitivity to the product or any of its components.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..