Keppra Indication:

Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.

Keppra Mechanism Of Action:

The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizures. Keppra did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization. Keppra also displayed inhibitory properties in the kindling model in rats, another model of human complex partial seizures, both during kindling development and in the fully kindled state. The predictive value of these animal models for specific types of human epilepsy is uncertain.

Keppra Drug Interactions:

Carbamazepine This association may increases the risks of carbamazepine toxicity

Keppra Food Interactions:

Take without regard to meals. Food does not affect bioavailabilty.

Keppra Generic Name:

Synonyms:

  • Levetiracetam [INN]
  • Levetiracetamum [INN-Latin]
  • Levitiracetam

Drug Type:

Small Molecule; Approved; Investigational

Absorption:

Rapidly and almost completely absorbed after oral administration (99%). Peak plasma concentrations occurring in about an hour following oral administration in fasted subjects.

Toxicity (Overdose):

Side effects include aggression, agitation, coma, drowsiness, reduced consciousness, slowed breathing

Protein Binding:

Very low (<10%)

Biotransformation:

The major metabolic pathway of levetiracetam (24% of dose) is an enzymatic hydrolysis of the acetamide group. No CYP450 metabolism detected.

Half Life:

6-8 hours

Dosage Forms of Keppra:

Tablet Oral

Chemical IUPAC Name:

(2R)-2-(2-oxopyrrolidin-1-yl)butanamide

Organisms Affected:

Humans and other mammals

Keppra to general, pharmacology

General, pharmacology..
Anticonvulsants