Klonopin

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses. .
[PubChem].

Medicinal name:
  • Clonazepam 0.5 MG Oral Tablet [Klonopin]
  • Clonazepam 2 MG Oral Tablet [Klonopin]
  • Clonazepam 1 MG Oral Tablet [Klonopin]

Klonopin - Pharmacology:

Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Klonopin mini report

Klonopin NDA
NDA - A product marketed under an approved New Drug Application
Klonopin HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Klonopin global name
Clonazepam
Klonopin global name
clonazepam
Start - Stop data
START DATA:
1975-Jun-02
Start - Stop data
STOP DATA
not occurred

Klonopin for patients

Klonopin is used for the treatment of seizures. Notify your physician if you
are pregnant or nursing. This medication may cause dizziness, drowsiness, or
blurred vision; use caution while driving or operating hazardous machinery.
Do not take any other sedating drugs or drink alcohol while taking clonazepam.
Do not change the dose or stop taking clonazepam without talking with your physician.
This medication may be habit forming. Seizures or withdrawal symptoms may occur after
you stop taking it. This medication should be taken with meals to avoid stomach upset.

Klonopin Interactions

Effect of Klonopin on the Pharmacokinetics of Other Drugs: Klonopin does not appear to alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. The effect of clonazepam on the metabolism of other drugs has not been investigated.

Effect of Other Drugs on the Pharmacokinetics of Klonopin: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.

In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the Cmax of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone.

Fluoxetine does not affect the pharmacokinetics of clonazepam. Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels. Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam.

Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.

Klonopin Contraindications

Klonopin is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures. Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.

Manufacturers name:

  • Cardinal Health
  • STAT RX USA LLC
  • Genentech, Inc

Klonopin tags categories:

Generic name, Overdose, Half Life Klonopin, Food Interactions, Chemical, etc..

Klonopin see also FDA report

Brand Names containing Clonazepam