Lactulose

A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)

Lactulose - Pharmacology:

Lactulose is a synthetic sugar used in the treatment of constipation and liver disease. It consists of the monosaccharides fructose and galactose. In the colon, lactulose is broken down primarily to lactic acid, and also to small amounts of formic and acetic acids, by the action of via evolved-beta galactosidase from colonic bacteria, which results in an increase in osmotic pressure and slight acidification of the colonic contents. This in turn causes an increase in stool water content and softens the stool. In treating heptic diseases (hepatic encephalopathy) it is thought that lactulose draws out ammonia from the body in the same way that it draws out water into the colon.

Lactulose mini report

Lactulose ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Lactulose ORAL
ORAL
Lactulose ORAL; RECTAL
ORAL; RECTAL
Lactulose HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Lactulose global name
LACTULOSE
Lactulose global name
Lactulose
Lactulose global name
lactulose
Start - Stop data
START DATA:
1966-Jul-30
Start - Stop data
STOP DATA
not occurred

Lactulose Interactions

Results of preliminary studies in humans and rats suggest that nonabsorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with lactulose.

Lactulose Contraindications

Since KRISTALOSE™ (Lactulose) for Oral Solution contains galactose (less than 0.3 g/10 g as a total sum with lactose), it is contraindicated in patients who require a low galactose diet.

Generic name, Overdose, Half Life Lactulose, Food Interactions, Chemical, etc..

Lactulose see also Anise

Digestive Health & Nausea