For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.
Lamictal Mechanism Of Action:
One proposed mechanism of action of Lamictal, the relevance of which remains to be established in humans, involves an effect on sodium channels. in vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate).
Lamictal Drug Interactions:
Carbamazepine Carbamazepine decreases the effect of lamotrigine
Clozapine Lamictal increases the effect and toxicity of clozapine
Desogestrel The oral contraceptive decreases the effect of lamotrigine
Ethinyl Estradiol The oral contraceptive decreases the effect of lamotrigine
Mestranol The oral contraceptive decreases the effect of lamotrigine
Norethindrone The oral contraceptive decreases the effect of lamotrigine
Divalproex sodium Valproic acid increases the effect of lamotrigine
Ethotoin Phenytoin may reduce levels of lamotrigine
Fosphenytoin Phenytoin may reduce levels of lamotrigine
Mephenytoin Phenytoin may reduce levels of lamotrigine
Phenytoin Phenytoin may reduce levels of lamotrigine
Rifampin Rifampin decreases levels of lamotrigine
Methsuximide Methsuximide decreases the effect of lamotrigine
LD50=250 (mg/kg) (in rat, mice); LD50>640 orally (mg/kg) (in rat, mice) (Sawyer). Symptoms of overdose include decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, and rolling eyeballs.
Chemical IUPAC Name: