Lamisil

Lamisil hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene epoxidase, an enzyme that is part of the fungal cell wall synthesis pathway.

Medicinal name:
  • Terbinafine 250 MG Oral Tablet [Lamisil]

Lamisil - Pharmacology:

Lamisil is hypothesized to act by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes.

Lamisil mini report

Lamisil NDA
NDA - A product marketed under an approved New Drug Application
Lamisil TOPICAL
TOPICAL
Lamisil ORAL
ORAL
Lamisil CREAM
CREAM
Lamisil GRANULE
GRANULE
Lamisil LIQUID
LIQUID
Lamisil SPRAY
SPRAY
Lamisil TABLET
TABLET
Lamisil HUMAN OTC DRUG
HUMAN OTC DRUG
Lamisil HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Lamisil global name
TERBINAFINE HYDROCHLORIDE
Lamisil global name
terbinafine hydrochloride
Lamisil global name
Terbinafine Hydrochloride
Start - Stop data
START DATA:
2005-Aug-10
Start - Stop data
STOP DATA
not occurred

Lamisil for patients

Patient Information:

Discuss with you doctor about the risks of this medication before taking it.
Do not dring alcohol while you are taking Lamisil, because liber problem may
occur. Contack you doctor if you experience any discomforts, for example, nausea, vomiting, loss of appetite,
yellow eys or skin.
Finsh the medication even if you feel better.

Lamisil Interactions

In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, and cyclosporine. In vitro studies have also shown that terbinafine inhibits CYP2D6-mediated metabolism. This may be of clinical relevance for compounds predominantly metabolized by this enzyme, such as tricyclic antidepressants, ß-blockers, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAO-Is) Type B, if they have a narrow therapeutic window.

In vivo drug-drug interaction studies conducted in normal volunteer subjects showed that terbinafine does not affect the clearance of antipyrine or digoxin. Lamisil decreases the clearance of caffeine by 19%. Lamisil increases the clearance of cyclosporine by 15%.

There have been spontaneous reports of increase or decrease in prothrombin times in patients concomitantly taking oral terbinafine and warfarin, however, a causal relationship between LAMISIL® Tablets and these changes has not been established.

Lamisil clearance is increased 100% by rifampin, a CyP450 enzyme inducer, and decreased 33% by cimetidine, a CyP450 enzyme inhibitor. Lamisil clearance is unaffected by cyclosporine.

There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, theophyllines, phenytoins, thiazide diuretics, beta blockers, and calcium channel blockers.

Lamisil Contraindications

LAMISIL® (terbinafine hydrochloride tablets) Tablets are contraindicated in individuals with hypersensitivity to terbinafine or to any other ingredients of the formulation.

Manufacturers name:

  • Novartis Pharmaceuticals Corporation

Generic name, Overdose, Half Life Lamisil, Food Interactions, Chemical, etc..

Lamisil see also FDA report Pink Lotus

Brand Names containing Terbinafine
Anti Fungal