Leukeran

A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin&

Medicinal name:
  • Leukeran 2 MG Oral Tablet
  • Chlorambucil 2 MG Oral Tablet [Leukeran]

Leukeran - Pharmacology:

Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

Leukeran mini report

Leukeran NDA
NDA - A product marketed under an approved New Drug Application
Leukeran TABLET, FILM COATED
TABLET, FILM COATED
Leukeran HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Start - Stop data
START DATA:
1985-Feb-13
Start - Stop data
STOP DATA
not occurred

Leukeran Interactions

There are no known drug/drug interactions with chlorambucil.

Leukeran Contraindications

Leukeran should not be used in patients whose disease has demonstrated a prior resistance to the agent. Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug.There may be cross-hypersensitivity (skin rash) between chlorambucil and other alkylating agents.

Manufacturers name:

  • GlaxoSmithKline LLC
  • Aspen Global Inc

Generic name, Overdose, Half Life Leukeran, Food Interactions, Chemical, etc..

Leukeran see also FDA report

Brand Names containing Chlorambucil
Cancer